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    UZH 3R Award 2024

    Better Surgical Practice Improves Rodent Welfare

    Mandatory guidelines and training: this is how experimental surgery on mice can be optimized. Petra Seebeck and her team from Zurich Integrative Rodent Physiology won this year’s UZH 3R Award for the project. The second prize went to Benjamin Ineichen and his STRIDE Lab for the promotion of systematic literature searches.
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    Portrait — Onur Boyman

    Researcher, Founder, Helper

    Onur Boyman became a doctor because he wanted to help people. Now, having achieved a breakthrough with his research on autoimmune diseases, the UZH professor plans to bring a new therapy to market – and switch role from head of clinic to entrepreneur.
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    2024 Koetser Award

    Eminent Neuroscientist and Violinist Honored

    Professor Klaus Toyka has received the 2024 Betty and David Koetser Award for Brain Research in recognition of his pioneering experimental and clinical contributions in the field of inflammatory diseases of the nervous system.
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    Genome editing

    Use of Genetic Scissors Carries Risks

    The CRISPR tool is capable of repairing the genetic defect responsible for the immune disease chronic granulomatous disease. However, researchers at the University of Zurich have now shown that there is a risk of inadvertently introducing other defects.
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    Medicine

    Unraveling the Link Between Hepatitis and Kidney Damage

    The hepatitis E virus affects the liver. But infected liver cells secrete a viral protein that reacts with antibodies in the blood and may form complexes that can damage the filter structure of the kidneys, as researchers from the University of Zurich and the University Hospital Zurich have proven for the first time.
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    Evolutionary Medicine

    Birth: It’s a Tight Squeeze for Chimpanzees, Too

    A new study shows that chimpanzees, like humans, must contend with a confined bony birth canal when giving birth. The “obstetrical dilemma” therefore evolved gradually over the course of primate evolution rather than suddenly in humans as originally argued.
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    Microbiology

    AI Helps to Detect Antibiotic Resistance

    In a pilot study, researchers at the University of Zurich have used artificial intelligence to detect antibiotic resistance in bacteria for the first time. This is an important first step toward integrating GPT-4 into clinical diagnostics.
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    Medicine

    Deciphering Blood

    Brain tumors are difficult to diagnose and treat. Neurologist Tobias Weiss is researching a new method for detecting brain tumors that uses clues present in blood samples. His method utilizes cellular particles called extracellular vesicles, which have proven to be promising biomarkers.
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    Travel medicine

    Novel App Tracks Travel-Related Illnesses

    About one in three people who travel gets sick, often with gastrointestinal and respiratory symptoms, a travel app developed by UZH researchers finds. The app could be used in the future to help detect outbreaks of contagious diseases at an early stage.
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    Clinical translation

    Compact “Gene Scissor” Enables Effective Genome Editing

    TnpB is an ancestor of the well-known “gene scissor” CRISPR-Cas, but is much smaller and thus easier to transport into cells. Using protein engineering and AI algorithms, UZH researchers have now enhanced TnpB capabilities to make DNA editing more efficient and versatile, paving the way for treating a genetic defect for high cholesterol in the future.
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    Research Funding

    Three UZH Researchers Awarded SNSF Consolidator Grants

    The Swiss National Science Foundation (SNSF) has approved Consolidator Grants for three projects at the University of Zurich. Additionally, 14 early-career researchers at UZH benefit from the SNSF funding program Ambizione.
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    Paleogenetics

    Ancient Ailments

    Infectious diseases like the plague, leprosy and syphilis have made history and shaped humanity over a long period of time – are still doing so today. The paleogeneticist Verena Schünemann explores the evolution of pathogens and the question of why they have been able to survive for so long.
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    One Health

    Influenza viruses can use two entry points

    Most influenza viruses enter human or animal cells through specific pathways on the cells’ surface. UZH researchers have now discovered that certain human flu viruses and avian flu viruses can also use a second entry pathway to infect cells.
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    Tumor biology

    Key Driver for Epithelial Cancer Development Identified

    A distinct signaling pathway called TNF-α drives the transformation of epithelial cells into aggressive tumor cells. During cancer progression, cells activate their own TNF-α program and become invasive - they spread into other organs.
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    Mental health

    Striving for Perfection

    In our interview child and adolescent psychologist Dagmar Pauli talks about the influence of school and social media, boys with gaming addictions, and the problems facing transgender youth.
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    Animal research and 3Rs

    UZH Researchers Win Swiss 3R Awards

    This year’s awards from the Swiss 3R Competence Centre all go to UZH scientists whose research contributes to replacing, reducing and refining animal experiments.
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