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World Premiere in Zurich: Machine Keeps Human Livers Alive for One Week Outside of the Body

Researchers from the UniversityHospital Zurich, ETH Zurich, Wyss Zurich and the University of Zurich have developed a machine that repairs injured human livers and keeps them alive outside the body for one week. This breakthrough may increase the number of available organs for transplantation, saving many lives of patients with severe liver diseases or cancer.

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A surgeon connects the donor liver to the perfusion machine. (USZ)
A surgeon connects the donor liver to the perfusion machine. (USZ)

Until now, livers could be stored safely outside the body for only a few hours. With the novel perfusion technology, livers - and even injured livers - can now be kept alive outside of the body for an entire week. This is a major breakthrough in transplantation medicine, which may increase the number of available organs for transplantation and save many lives of patients suffering from severe liver disease or a variety of cancers. Injured cadaveric livers, initially not suitable for use in transplantation, may regain full function while perfused in the new machine for several days. The basis for this technology is a complex perfusion system, mimicking most core body functions close to physiology. The corresponding study was published on 13 January in the journal Nature Biotechnology.

 

Offering what other machines cannot

"The success of this unique perfusion system - developed over a four-year period by a group of surgeons, biologists and engineers - paves the way for many new applications in transplantation and cancer medicine helping patients with no liver grafts available," explains Prof. Pierre-Alain Clavien, Chairman of the Department of Surgery and Transplantation at the UniversityHospital Zurich (USZ). When the project started in 2015, livers could only be kept  on the machine for 12 hours. The seven-day successful perfusion of poor-quality livers now allows for a wide range of strategies, e.g. repair of preexisting injury, cleaning of fat deposits in the liver or even regeneration of partial livers.

 

Liver4Life: A project from Wyss Zurich

The Liver4Life project was developed under the umbrella of Wyss Zurich institute, which brought together the highly specialized technical know-how and biomedical knowledge of experts from the UniversityHospital Zurich (USZ), ETH Zurich and the University of Zurich (UZH). "The biggest challenge in the initial phase of our project was to find a common language that would allow communication between the clinicians and engineers," explains Prof. Philipp Rudolf von Rohr, professor of process engineering at ETH Zurich and co-leader with professor Clavien of the study now published in Nature Biotechnology.

 

Technology with great potential

The inaugural study shows that six of ten perfused poor-quality human livers, declined for transplantation by all centers in Europe, recovered to full function within one week of perfusion on the machine. The next step will be to use these organs for transplantation. The proposed technology opens a large avenue for many applications offering a new life for many patients with end-stage liver disease or cancer.

 

Publication:

Dilmurodjon Eshmuminov, Dustin Becker, Lucia Bautista Borrego, Max Hefti, Martin J. Schuler, Catherine Hagedorn, Xavier Muller, Matteo Mueller, Christopher Onder, Rolf Graf, Achim Weber, Philipp Dutkowski, Philipp Rudolf von Rohr and Pierre-Alain Clavien. An integrated perfusion machine preserves injured human livers for one week. Nature Biotechnology. Doi : 10.1038/s41587-019-0374-x

https://www.nature.com/articles/s41587-019-0374-x

Weiterführende Informationen

Contact

Pierre-Alain Clavien, Prof. Dr. med.

Director of the Clinic for Visceral and Transplant Surgery at University Hospital Zurich

 

Philipp Rudolf von Rohr, Prof. Dr.

Department for Machine Engineering and Process Technology, Institute for Process Technology, Laboratory for Transport Processes and Reactions

 

Contact through the UHZ media office: medien@usz.ch, +41 44 255 86 20

 

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  • A surgeon connects the donor liver to the perfusion machine. (USZ)

    (JPG, 423 KB)

    A surgeon connects the donor liver to the perfusion machine. (USZ)

  • The perfusion machine in operation. The donor liver is connected in the white container in the upper left. (USZ)

    (JPG, 462 KB)

    The perfusion machine in operation. The donor liver is connected in the white container in the upper left. (USZ)

  • On the left a non-perfused liver, on the right a liver treated with the new machine. (USZ)

    (JPG, 446 KB)

    On the left a non-perfused liver, on the right a liver treated with the new machine. (USZ)

  • The perfusion machine replaces the functions of various organs in order to keep the donor liver alive outside of the body. (USZ)

    (PNG, 506 KB)

    The perfusion machine replaces the functions of various organs in order to keep the donor liver alive outside of the body. (USZ) (Image: beamue)